4) VENOM
Partially composed of a symbiote that Spider-Man picked up on the composite planet assembled by the Beyonder in Secret Wars (EVERYBODY GOT THAT?), Venom is rough, tough, carnivorous and puts the “Ugh” in ugly. But, as Spider-Man discovered when it was his costume, that symbiote has a particular weakness for powerful sonic waves, allowing him to finally rid himself of it thanks to the peal of church bells. Though several individuals have bonded with the symbiote to become Venom over the years, that weakness to sonic attacks remains…
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If we include non-television material, Aspirin can be fatal to the Doctor (and other Time Lords). This was never explicitly stated within the TV series, but is within novels and audio dramas. However, there IS an episode of the TV series where Jo offers the Third Doctor an Earth medicine tablet, which he states could kill him, and while it was not directly said to be Aspirin in the episode, many fans speculate it was an Aspirin tablet after the subject was stated in later non-televised works.